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Knowledge is not fixed, but instable, uncertain and evolving. On the occasion of Tobias Rees’ sojourn as a ZGW academic guest, the workshop « The Emergence and Dissolution of (Medical) Knowledge » asks how the uncertainty, instability and ambivalences of knowledge that Rees identifies in his brand-new book Plastic Reason (http://www.ucpress.edu/book.php?isbn=9780520288133) play out in fields as diverse as brain science, stem cell research, mental illness, IVF, and surrogacy.