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Delving into the critical topic of human trials for artificial womb technologies, Alice Cavolo and her colleague Daniel Pizzolato share insights in their latest academic publication in Prenatal Diagnosis. They meticulously examine the challenges inherent in conducting randomized controlled trials for this innovative technology, advocating for a nuanced approach. Exploring the complexities involved, they propose the merits of a single-arm trial, arguing it could better serve both participants and scientific advancement. Their discussion also focuses on safeguarding the welfare of participants, particularly infants and pregnant individuals, within such trials.